The NCBI Clusters of Orthologous Groups (COG) system uses evolutionary relationships to cluster proteins from different genomes into different functional categories. OntoCOG is an ontology-based Semantic Web application for COG-based gene set enrichment analysis.

Simple tutorial:

Here is the program:

(1) Select one species
(2) Input protein GIs: Example 1, Example 2 (Protein Virulence factor)



Lin Y, Xiang Z, He Y. Towards a Semantic Web application: Ontology-driven ortholog clustering analysis. Proceedings of the 2nd International Conference on Biomedical Ontologies (ICBO-2011), Buffalo, NY, USA, July 28-30, 2011. Page 33 - 40. [http://ceur-ws.org/Vol-833/paper5.pdf]; [Presentation Slides: PDF, PPT] .